Every corner of America has a sandwich worth traveling for, but some are still waiting for their moment in the spotlight. This list brings together 15 unforgettable regional classics, each with a story, a strong following, and an unforgettable bite. If you’re looking for something different, these sandwiches will take your tastebuds on a cross-country adventure.
Fried Pork Tenderloin Sandwich

Maddy Alewine / Them Bites
Indiana’s fried pork tenderloin is all about a huge, crispy cutlet that spills over the bun, piled with pickles and onions. It’s a Midwestern rite of passage. Get the recipe.
Pepperoni Rolls

Maddy Alewine / Them Bites
West Virginia miners made this simple roll with sticks of pepperoni tucked inside soft dough. It’s grab-and-go lunch at its finest, and completely unique to the Mountain State. Try it here.
Pork Chop Sandwich

Maddy Alewine / Them Bites
Montana’s contribution is a fried pork chop in a bun. It’s straightforward, hearty, and perfect for a quick meal after a day outdoors. See how it’s made.
Hot Brown Sandwich

Maddy Alewine / Them Bites
Louisville’s legendary open-faced turkey sandwich, covered with bacon and creamy Mornay sauce, then broiled until golden. It’s rich, decadent, and a Kentucky essential. Try the original.
Shrimp Po Boy

Maddy Alewine / Them Bites
Louisiana’s favorite street food: crunchy fried shrimp in a French roll with lettuce, tomato, pickles, and remoulade. You won’t forget this one. See the recipe.
Olive Burger

Maddy Alewine / Them Bites
Michigan’s quirky classic loads green olive mayo atop a juicy beef patty. It’s briny, beefy, and surprisingly addictive. Try a bite.
Primanti Brothers Sandwich

Maddy Alewine / Them Bites
Pittsburgh’s icon stacks coleslaw and fries right in the sandwich, alongside meats, cheeses, and tomato. Complete meal in every bite. Meet the legend.
Sonoran Hot Dog

Maddy Alewine / Them Bites
Tucson, Arizona’s creation is a bacon-wrapped hot dog topped with pinto beans, tomatoes, onions, jalapeños, and a drizzle of crema. It’s spicy, creamy, and crunchy all at once. Build your own.
Bobbie Sandwich

Maddy Alewine / Them Bites
Delaware’s most famous sandwich is Thanksgiving on a roll: turkey, cranberry sauce, stuffing, and mayo. It’s comfort food year-round. Taste the tradition.
St. Paul Sandwich

Maddy Alewine / Them Bites
This St. Louis original fills white bread with an egg foo young patty, lettuce, pickles, and mayo. It’s a Chinese-American classic gone Midwestern. Try something new.
Loose Meat Sandwich

Maddy Alewine / Them Bites
Iowa’s no-nonsense beef sandwich lets you pick your own toppings. It’s comfort food that never fails. Get the recipe.
Cudighi Sandwich

Maddy Alewine / Them Bites
Upper Peninsula Michigan’s spicy Italian sausage, topped with marinara and mozzarella on a hoagie roll. It’s hearty and always hits the spot. Dig in.
Jucy Lucy

Maddy Alewine / Them Bites
Minneapolis’s Jucy Lucy is a burger with the cheese inside the patty. Bite in, and you get a river of melted cheese with every mouthful. Experience the ooze.
North Shore Beef

Maddy Alewine / Them Bites
From Massachusetts, this roast beef sandwich is thinly sliced, piled high, and best with “three-way” style;cheese, mayo, and barbecue sauce. Discover the classic.
Sailor Sandwich

Maddy Alewine / Them Bites
Richmond, Virginia’s rye bread classic, layered with pastrami, grilled knackwurst, Swiss cheese, and a good schmear of mustard. Set sail.